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From reformulation to portion control, appetite suppression to satiety science - the GLP-1 revolution is reshaping how we think about food innovation and weight management

The Phase 2 trial of retatrutide (Jastreboff et al., New England Journal of Medicine , 2023) reported that the most common adverse effects were gastrointestinal in nature (nausea, vomiting, diarrhoea), consistent with the GLP-1 receptor agonist class

The N-terminal region of GLP-1 is considered critical for receptor activation, whereas the C-terminal region predominantly facilitates receptor binding

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